姓名 | 左志成(Zhicheng Zuo) | ||
办公地点 | 4号实训楼4413 | ||
办公电话 | 152*2143*2062 | ||
电子邮箱 | ZhichengZuo@sues.edu.cn | ||
毕业学校 | 复旦大学 | ||
研究领域 计算结构生物学、计算化学 研究(招生)方向 1. 生物大分子结构、动力学行为与功能的关系。 2. 蛋白酶催化机理研究、蛋白酶活性与特异性的理性优化。 3. 基于结构的药物理性设计与优化。 | |||
个人简历 2019/04-至今, 上海工程技术大学, 化学化工学院, 副教授(硕导) 2016/03-2019/04, (美国)北德州大学健康科学中心, 药学院, 博士后(计算化学) 2012/09-2016/01, 复旦大学, 化学系, 博士(物理化学) 2009/09-2012/07, 北京工业大学, 生命科学与生物工程学院, 硕士(生物物理) 2005/09-2009/07, 山东大学,海洋学院, 学士(生物科学)
承担项目 1. 国家自然科学基金—青年基金项目(2021.01~2023.12) 2. 上海市青年DF学者岗位资助(2019~2021) 荣誉奖项 1.2018年上海市青年DF学者 教师寄语:书山有路勤为径,学海无涯苦作舟。
招生要求:勤奋刻苦、坐得住冷板凳、执行力强。欲混日子、混学历者,敬请远离!
主讲课程:《药物设计学》、《生物技术制药》、《计算机辅助药物设计》 | |||
代表性论著 期刊论文: 【1】 Zhicheng Zuo, Kesavan Babu, Chhandosee Ganguly, Ashwini Zolekar, Sydney Newsom, Rakhi Rajan, Yu-Chieh Wang, Jin Liu. Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-dependent Off-target Effects (in press). The CRISPR Journal. 2022. DOI: 10.1089/crispr.2021.0076【IF=6.071,中科院二区】 【2】 Collias, D., R. T. Leenay, R. A. Slotkowski, Zhicheng Zuo, S. P. Collins, B. A. McGirr, J. Liu, and C. L. Beisel. A positive, growth-based PAM screen identifies noncanonical motifs recognized by the S. pyogenes Cas9. Science advances, 2020, 6 (29), eabb4054. 【3】Zhicheng Zuo; Jin Liu*; Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage, Current Opinion in Structural Biology, 2020, 62:166-174【IF=7.052,中科院二区】 【4】Zhicheng Zuo, Ashwini Zolekar, Kesavan Babu, Victor JT Lin, Hamed S Hayatshahi, Rakhi Rajan, Yu-Chieh Wang, Jin Liu. eLife 2019, 8:e46500【IF=7.551,中科院一区】 【5】Zhicheng Zuo & Jin Liu. Assessing the Performance of the Nonbonded Mg2+ Models in a Two-Metal-Dependent Ribonuclease.Journal of Chemical Information and Modeling, 2019, 59:399-408【IF=3.966,中科院二区】 【6】Zhicheng Zuo, Rachel Smith, Zhenglan Chen, Amruta Agharkar, Heather Snel, Ren-qi Huang, Jin Liu, Eric Gonzales. Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3. Nature Communication, 2018, 9(1):2082【IF=11.878,中科院一区】 【7】Yinjuan Chen, Zhicheng Zuo, Xinhua Dai, Peng Xiao, Xiang Fang, Wenning Wang, Chuan-Fan Ding. Gas-phase Complexation of α-/β-cyclodextrins with Amino Acids Studied by Ion Mobility-Mass Spectrometry and MolecularDynamics Simulations. Talanta, 2018, 186:1-7 【8】Zhicheng Zuo & Jin Liu. Structure and Dynamics of Cas9 HNH Domain Catalytic State. Scientific Reports, 2017, 7:17271. 【9】Zhicheng Zuo & Jin Liu. Cas9-catalyzed DNA Cleavage Generates Staggered Ends: Evidence from Molecular Dynamics Simulations. Scientific Reports, 2016, 6:37584. 【10】Zhicheng Zuo, Jingwei Weng & Wenning Wang. Insights into the Inhibitory Mechanism of D13-9001 to the Multidrug Transporter AcrB through Molecular Dynamics Simulations. Journal of Physical Chemistry B, 2016, 120:2145-2154. 【11】Zhicheng Zuo, Beibei Wang, Jingwei Weng & Wenning Wang. Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB. Scientific Reports, 2015, 5:13905. 【12】Chunhua Li*, Zhicheng Zuo, Jiguo Su, Xianjin Xu & Cunxing Wang. The interactions and recognition of cyclic peptide mimetics of Tat with HIV-1 TAR RNA: a molecular dynamics simulation study. Journal of Biomolecular Structure and Dynamics, 2013, 31:276-287.
专利:
1. Jin Liu; Zhicheng Zuo; Yu-Chieh Wang; ENGINEERED CAS9 VARIANTS, International Application No.: PCT/US2018/050279. (Publication Number: WO/2019/051419; Publication Date: 14.03.2019) 更新于2022年3月2日 |