陆杰

姓    名

陆杰(Lu Jie)  教授 / 博士生导师

办公地点

3号实训楼3411

办公电话

15800851286

电子邮箱

lujie@sues.edu.cn

毕业学校

天津大学

研究方向

1. 工业结晶与药物结晶

2. 纳米晶体功能材料

3. 选择性分离与化工系统工程

4. 资源与环境化工

个人简历

2014/01 - 至今, 上海工程技术大学, 化学化工学院, 教授

2009/03-2014/01, 江南大学, 粮食发酵工艺与技术国家工程实验室, 教授

2008/03-2009/02, 加拿大西安大略大学, 化学与生物工程系, 研究员

2001/08-2008/01, 新加坡南洋理工大学, 化学与生物医学工程学院, 高级研究员

1999/06-2001/08, 上海大学, 环境与化学工程学院, 副教授

1997/05-1999/04, 华南理工大学, 博士后, 导师: 陈焕钦教授

1994/03–1997/03, 天津大学, 化学工程, 博士, 导师: 王静康院士

1991/09–1994/03, 天津大学, 化学工程, 硕士, 导师: 李绍芬教授

1987/09–1991/07, 天津大学, 化学工程, 学士, 导师: 贾绍义教授

代表性项目

1. 国家自然科学基金重大研究计划项目（培育）(92156020)“药物分子晶体组装的手性传递及其调控机制研究”(2022/01-2024/12)

2. 国家自然科学基金面上项目(22078191)“纳米纤维素凝胶中药物多晶型形成机理研究”(2021/01-2024/12)

3. 国家自然科学基金国际(地区)合作交流项目(22081340412)“中韩功能产品智能化与智慧生产管理”(2020/02-2021/12)

4. 国家自然科学基金面上项目(21978165)“模板介导药物纳米晶体精准组装的多尺度研究”(2020/01-2023/12)

5. 国家自然科学基金面上项目(21476136)“生物胶体中晶体的自组装及转变机理研究：以胆固醇结石为例”(2015/01-2018/12)

6. 上海市科委重点支撑项目(15430501200)“药物晶体组装与调控共性关键技术开发”(2015/11-2020/12)

7. 国家自然科学基金国际(地区)合作研究项目(GZ935)“Toward Further Understanding and Higher Efficiency of Protein Crystallization”(2014/01-2017/12)

8. 江苏省科技厅，江苏省自然科学基金项目(BK20131100)“药物分子多晶型结晶的机理及控制研究”(2013/07-2016/06)

9. 江苏省环保厅，江苏省环保科研课题(2012004)“高盐度工业废水的绿色循环处理新技术及其应用”(2012/08-2014/07)

10. 国家自然科学基金面上项目(21176102)“蛋白质分子晶体的二维自组装研究”(2012/01-2015/12)

11. 国家自然科学基金面上项目(21176215)”恶臭假单胞菌扁桃酸消旋酶催化底物多样性产生机制的研究”(2012/01-2015/12)

12. 国家自然科学基金国际(地区)合作交流项目(GZ843)“Fundamentals and Cutting-Edge Technologies of Industrial Crystallization”(2012/01-2012/12)

13.国家自然科学基金青年项目(20106010)“生物大分子结晶机理及其控制结晶技术研究”(2002/01-2004/12)

荣誉奖项

2022 国家一流本科专业化学工程与工艺负责人

2021 全国石油和化工教育优秀教学团队负责人

2018 上海市科技进步二等奖

2014 中国轻工业联合会科技进步三等级

2013 中国商业联合会科技进步一等奖

2010 中国轻工业联合会科技进步三等级

2001 教育部“高等学校骨干教师”

社会兼职

委员：ACS、中国化工学会第1届医药化工专业委员会、中国药学会药物晶体工程小组，等

编辑：Journal of Chemical Research and Application，American Journal of Chemical Engineering，Current Chinese Science，等

评审：

中国国家基金委各类项目(2012-)

教育部博士点基金及学位与研究生教育(2013-)

上海市学位与研究生教育(2015-)

上海市科技奖励(2018-)

国家科技奖励(2019-)

上海市生态环境应急管理(2021-)

科技部各类专项与研发计划（2022-）, 等

代表性论著（论文、著作、专利）

1. Lei-Lei Zhang#, Yue Xu#, Bo-Xuan Lou, Xiao-Lan Qin, Li-Juan Zhang, Xi-Jian Liu, Hai-Kuan Yuan, Yan Zhang, Sohrab Rohani, Jie Lu*. Effect of additives on preferential crystallization for the chiral resolution of citrulline: experimental, statistical, and molecular dynamics simulation studies. Crystal Growth & Design, 2022, 22(4), 2392-2406.

2. Jiang-Hao Zhang#, Bo-Xuan Lou#, Xiao-Lan Qin, Yin-Wen Li, Hai-Kuan Yuan, Li-Juan Zhang, Xi-Jian Liu, Yan Zhang, Jie Lu*. Using amphiphilic polymer micelles as the templates of antisolvent crystallization to produce drug nanocrystals. ACS Omega, 2022, 7(24), 21000−21013.

3. Jiao-Jiao Cao#, Bo-Xuan Lou#, Yue Xu#, Xiao-Lan Qin, Hai-Kuan Yuan, Li-Juan Zhang, Yan Zhang, Sohrab Rohani, Jie Lu*. Direct crystallization resolution of racemates enhanced by chiral nanorods: experimental, statistical, and quantum mechanics/molecular dynamics simulation studies. ACS Omega, 2022, 7(23), 19828−19841.

4. 王东博, 张蕾蕾, 翟晶焕, 张丽娟, 刘锡建, 朱雪焱, 陆杰*. 青霉胺结晶热力学及拆分工艺研究. 化工学报, 2021, 72(4), 1885-1894.

5. Ran-Ran Sun, Xiao-Meng Guo, Da-Wei Yang, Ya-Lin Tang, Jie Lu*, Hong-Xia Sun*. c-Myc G-quadruplex is sensitively and specifically recognized by a fluorescent probe. Talanta, 2021, 226, 122125.

6. Dong-Bo Wang, Jie Lu*, Lei-Lei Zhang, Fan-Fan Fan, Li-Juan Zhang, Xi-Jian Liu, Hai-Kuan Yuan, Xue-Yan Zhu. Experimental and molecular dynamics simulation study on the primary nucleation of penicillamine racemate and its enantiomers in the mixture solvent of water and ethanol. Industrial & Engineering Chemistry Research, 2020, 59(50), 21957−21968.

7. Jing-Jiao Sui, Ying Luo, Jing-Huan Zhai, Fan-Fan Fan, Li-Juan Zhang, Jie Lu,* Xue-Yan Zhu. Solubility measurement, model evaluation and molecular simulations of aprepitant (form I) in eight pure solvents. Journal of Molecular Liquids, 2020, 112723.

8. Xiao-Di Liu#, Hai-Kuan Yuan#*, Cheng-Cong Wang, Shuai Zhang, Li-Juan Zhang, Xi-Jian Liu, Feng-Jiao Liu, Xue-Yan Zhu, Sohrab Rohani, Chi-Bun Ching, Jie Lu*. A novel PVDF/PFSA-g-GO ultrafiltration membrane with enhanced permeation and antifouling performances. Separation and Purification Technology, 2020, 233, 116038.

9. Min-Yi Zhang#, Xi-Jian Liu#*, Qian Luo#, Qi Wang, Lin-Jing Zhao, Guo-Ying Deng, Ren-Bin Ge, Lei Zhang*, Jun-Qing Hu, Jie Lu*. Tumor environment responsive degradable CuS@mSiO2@MnO2/DOX for MRI guided synergistic chemo-photothermal therapy and chemodynamic therapy. Chemical Engineering Journal, 2020, 124450.

10. Wen-Yan Kong#, Qi Wang#, Guo-Ying Deng, Hang Zhao, Lin-Jing Zhao, Jie Lu*, Xi-Jian Liu*. Se@SiO2@Au-PEG/DOX NCs as a multifunctional theranostic agent: efficiently protect normal cells from oxidative damage during photothermal therapy. Dalton Transactions, 2020, 48(7), 2209−2217.

11. Fan-Fan Fan#, Hai-Kuan Yuan#, Yong-Hao Feng, Feng-Jiao Liu, Li-Juan Zhang, Xi-Jian Liu, Xue-Yan Zhu, Wei An, Sohrab Rohani, Jie Lu*. Molecular simulation approaches for the prediction of unknown crystal structures and solubilities of (R)- and (R,S)-crizotinib in organic solvents. Crystal Growth & Design, 2019, 19(10), 5882−5895.

12. Lan-Fang Ren#, Xi-Jian Liu#*, Tao Ji, Guo-Ying Deng, Feng-Jiao Liu, Hai-Kuan Yuan, Jing Yu, Junqing Hu, Jie Lu*. “All-in-one” theranostic agent with seven functions based on Bi-doped metal chalcogenides nanoflowers. ACS Applied Materials & Interfaces, 2019, 11(49), 45467−45478.

13. Ling Zhang, Xi-Jian Liu*, Min Zhang, Hai-Kuan Yuan, Li-Juan Zhang, Jie Lu*. Facile construction of dual functional Fe3O4@C-MoO2-Ni composites for catalysis and adsorption. Applied Surface Science, 2019, 494, 783−794.

14. Yi-Ling Zhang, Da-Jiang Mei*, Yi Yang, Wang-Zhu Cao, Yuan-Dong Wu, Jie Lu*, Zhe-Shuai Lin*. Rational design of new chalcogenide with good infrared nonlinear optical performance: SrZnSnS4. Journal of Materials Chemistry C, 2019, 7, 8556−8561.

15. Xue-Xue Fan, Ya-Nan Xu, Tian-Du Sheng, Dong-Qing Zhao, Hai-Kuan Yuan, Feng-Jiao Liu, Xi-Jian Liu, Xue-Yan Zhu, Li-Juan Zhang*, Jie Lu*. Amperometric sensor for dopamine based on surface-graphenization pencil graphite electrode prepared by in-situ electrochemical delamination. Microchimica Acta, 2019, 186, 324.

16. Guo-Chang Ma, Xi-Jian Liu*, Guo-Ying Deng, Hai-Kuan Yuan, Qiu-Gen Wang, Jie Lu*. A novel theranostic agent based on porous bismuth nanosphere for CT imaging guided combined chemo-photothermal therapy and radiotherapy. Journal of Material Chemistry B, 2018, 6, 6788−6795.

17. Shu-Ping Wu, Fan Wang, Hai-Kuan Yuan*, Li-Juan Zhang, Shi-Min Mao, Xi-Jian Liu, Njud S. Alharbi, Sohrab Rohani, Jie Lu*. Fabrication of xanthate-modified chitosan/poly(N-isopropylacrylamide) composite hydrogel for the selective adsorption of Cu(II), Pb(II) and Ni(II) metal ions. Chemical Engineering Research and Design, 2018, 139, 197−210.

18. Da-Wei Yan, Xi-Jian Liu*, Guo-Ying Deng, Hai-Kuan Yuan, Qiu-Geng Wang, Li-Juan Zhang, Jie Lu*. Facile assembling of novel polypyrrole nanocomposites theranostic agent for magnetic resonance and computed tomography imaging guided efficient photothermal ablation of tumors. Journal of Colloid and Interface Science, 2018, 530, 547−555.

19. Zhi Huang, Xi-Jian Liu*, Guo-Ying Deng, Hai-Kuan Yuan, Qiu-Gen Wang, Li-Juan Zhang, Jie Lu*. One-step assembly of CuMo2S3 nanocrystals for synergistic combination of photothermal therapy and photodynamic therapy. Dalton Transactions, 2018, 47, 5622−5629.

20. Xi-Jian Liu*, Ye-Ying Wang, Qi-Yang Yu, Guo-Ying Deng, Qian Wang, Xin-Hui Ma, Qiu-Gen Wang, Jie Lu*. Selenium nanocomposites as multifunctional nanoplatform forimaging guiding synergistic chemo-photothermal therapy. Colloids and Surfaces B: Biointerfaces, 2018, 166, 161−169.

21. Ye-Ying Wang, Xi-Jian Liu*, Guo-Ying Deng, Jian Sun, Hai-Kuan Yuan, Qi Li, Qiu-Gen Wang, Jie Lu*. Se@SiO2-FA-CuS nanocomposites for targeted delivery of DOX and nano selenium in synergistic combination of chemo-photothermal therapy. Nanoscale, 2018, 10, 2866−2875.

22. Fan Wang, Li-Juan Zhang*, Ye-Ying Wang, Xi-Jian Liu, Sohrab Rohani, Jie Lu*. Fe3O4@SiO2@CS-TETA functionalized graphene oxide for the adsorption of methylene blue (MB) and Cu (II). Applied Surface Science, 2017, 420, 970−981.

23. Ye-Ying Wang, Xi-Jian Liu*, Guo-Ying Deng, Qian Wang, Li-Juan Zhang, Qiu-Gen Wang, Jie Lu*. Multifunctional PS@CS@Au–Fe3O4–FA nanocomposites for CT, MR and fluorescence imaging guided targeted-photothermal therapy of cancer cells. Journal of Material Chemistry B, 2017, 5, 4221−4232.

24. Lan-Fang Ren, Xi-Jian Liu*, Qian Wang, Li-Juan Zhang, Guo-Ying Deng, Feng Zhou, Jie Lu*. Facile fabrication of a magnetically smart PTX-loaded Cys–Fe3O4/CuS@BSA nano-drug for imaging-guided chemo-photothermal therapy. Dalton Transactions, 2017, 46, 2204−2213.

25. Chang-Wei Xiao, Xi-Jian Liu*, Shi-Min Mao, Li-Juan Zhang, Jie Lu*. Sub-micron-sized polyethylenimine-modified polystyrene/Fe3O4/chitosan magnetic composites for the efficient and recyclable adsorption of Cu(II) ions. Applied Surface Science, 2017, 394, 378−385.

26. Jing-Huan Zhai, Zhen-Zhen Chen, Xi-Jian Liu, Li-Juan Zhang, Jie Lu*. Solubility measurement, model evaluation and thermodynamic analysis of rivaroxaban polymorphs in organic solvents. The Journal of Chemical Thermodynamics, 2017, 104, 218−229.

27. Zhi-Fang Gao, Xi-Jian Liu*, Ye-Ying Wang, Guo-Ying Deng, Feng Zhou, Qian Wang, Li-Juan Zhang, Jie Lu*. Facile one-pot synthesis of Fe3O4@chitosan nanospheres for MRI and fluorescence imaging guided chemo-photothermal combinational cancer therapy. Dalton Transactions, 2016, 45, 19519−19528.

28. Zhen-Zhen Chen, Jing-Huan Zhai, Xi-Jian Liu, Shi-Min Mao, Li-Juan Zhang, Sohrab Rohani, Jie Lu*. Solubility measurement and correlation of the form A of ibrutinib in organic solvents from 278.15 to 323.15 K. The Journal of Chemical Thermodynamics, 2016, 103, 342−348.

29. Zhi-Fang Gao, Xi-Jian Liu*, Guo-Ying Deng, Feng Zhou, Li-Juan Zhang, Qian Wang, Jie Lu*. Fe3O4@mSiO2-FA-CuS-PEG nanocomposites for magnetic resonance imaging and targeted chemo-photothermal synergistic therapy of cancer cells. Dalton Transactions, 2016, 45, 13456−13465.

30. Xi-Jian Liu*, Guo-Ying Deng, Ye-Ying Wang, Qian Wang, Zhi-Fang Gao, Yan-Gang Sun, Wen-Long Zhang, Jie Lu*, Jun-Qing Hu. A novel and facile synthesis of porous SiO2-coated ultrasmall Se particles as drug delivery nanoplatform for efficient synergistic treatment of cancer cells. Nanoscale, 2016, 8, 8536−8541.

31. Zhen-Xuan Fang, Xi-Jian Liu*, Mu-Dan Zhang, Jin-Rong Sun, Shi-Min Mao, Jie Lu*, Sohrab Rohani. A neural network approach to simulating the dynamic extraction process of L-phenylalanine from sodium chloride aqueous solutions by emulsion liquid membrane. Chemical Engineering Research and Design, 2016, 105, 188-199.

32. Mu-Dan Zhang, Zhen-Xuan Fang, Jing-Huan Zhai, Shi-Min Mao, Li-Juan Zhang*, Sohrab Rohani, Jie Lu*. Measurement and correlation of the solubility of rivaroxaban (form I) in binary mixtures of ethyl acetate with tetrahydrofuran, N,N-dimethylformamide, and N,N-dimethylacetamide from 278.15 to 318.15 K. The Journal of Chemical Thermodynamics, 2016, 94, 1−6.

33. Jin-Rong Sun, Li-Juan Zhang, Shi-Min Mao, Sohrab Rohani, Jie Lu*. Solid-liquid equilibrium of NaCl + HOCH2COONa + H2O system from (283.15 to 353.15) K. Fluid Phase Equilibria, 2016, 409, 334−340.

34. Guan Liu, Li-Juan Zhang*, Shi-Min Mao, Sohrab Rohani, Chi-Bun Ching, Jie Lu*. Zwitterionic chitosan-silica-PVA hybrid ultrafiltration membranes for protein separation. Separation and Purification Technology, 2015, 152, 55−63.

35. Zhen-Xuan Fang, Li-Juan Zhang, Si-Min Mao, Sohrab Rohani, Joachim Ulrich, Jie Lu*. Solubility measurement and prediction of clopidogrel hydrogen sulfate polymorphs in isopropanol and ethyl acetate. The Journal of Chemical Thermodynamics, 2015, 90, 71−78.

36. 刘锡建，任兰芳，陆杰. 铋掺杂的金属硫化物纳米花及其制备方法. 中国发明专利, ZL201910349442.X, 授权日期: 2021/09/17.

37. 王烨颖，刘锡建，陆杰. 一种偶联叶酸靶向的纳米复合粒子及其制备方法与应用. 中国发明专利, ZL201710092434.2, 授权日期: 2020/05/05.

38. 高志方, 刘锡建, 王烨颖, 王帆, 任兰芳, 陆杰. 偶联叶酸靶向的四氧化三铁/介孔二氧化硅/硫化铜纳米复合粒子及其制备方法和应用. 中国发明专利, ZL201610250533.4, 授权日期: 2020/04/07.

39. 马国昌，刘锡建，袁海宽，陆杰. 一种多孔铋纳米微球及其制备方法和应用. 中国发明专利, ZL201811008014.2, 授权日期: 2020/03/09.

40. 刘锡建, 陆杰, 王烨颖, 任兰芳, 邓国英, 王谦, 周峰. 一种金包覆硒化铜纳米粒子及其制备方法与应用. 中国发明专利, ZL201610557212.9, 授权日期: 2019/05/24.

41. 翟晶焕, 陈真真, 陆杰. 一种来那度胺与烟酰胺共晶的制备方法. 中国发明专利, ZL201610220805.6, 授权日期: 2018/10/26.

42. 高志方, 刘关, 陈真真, 翟晶焕, 陆杰. 一种抗蛋白质污染两性离子超滤膜及其制备方法. 中国发明专利, ZL201610136103.X, 授权日期: 2018/07/24.

43. 刘锡建, 陆杰, 孙彦刚, 张丽娟, 张红, 徐菁利. 一种多孔Se-SiO2纳米粒子及其制备方法和应用. 中国发明专利, ZL201510496173.1, 授权日期: 2017/12/29.

44. 陆杰, 林青, 周迅, 陈莲蔚, 吴丹辉. 一种制备无定形埃索美拉唑镁盐的结晶方法. 中国发明专利, ZL201310445802.9, 授权日期: 2015/01/07.

45. 陆杰, 李祯, 李义平, 汪晶. 一种制备一水合L-苯丙氨酸的结晶方法. 中国发明专利， ZL201110342607.4, 授权日期: 2014/05/21.

46. 陆杰, 汪晶, 李义平, 林青, 舒亮, 曾德利. 一种甲磺酸伊马替尼α晶型的制备方法. 中国发明专利, ZL201210098962.6, 授权日期: 2013/07/17.

47. 陆杰, 陈其林, 郭春荣, 叶勤, 李同斌. 一种从植物油脱臭馏出物中分离纯化甾醇的结晶方法. 中国发明专利, ZL200910223276.5, 授权日期: 2012/01/04.